"ICAPO seeks to ensure the widest possible integration of alternative methods in the OECD's influential guidelines and programmes."
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NEW: ICAPO partners with Laboratory of Mathematical Chemistry to Train EPA Regulators in OECD QSAR Toolbox
WASHINGTON (April 7, 2015) -- The International Council for Animal Protection in OECD Programmes (ICAPO) is proud to partner with the Laboratory for Mathematical Chemistry at the University of Bourgas, Bulgaria to offer training in the latest computational toxicology methods contained in the OECD QSAR Toolbox, a set of tools that allows the prediction of toxicological properties without animal testing, to regulators at the US Environmental Protection Agency. The training will be offered in a two-day intensive course repeated twice this week at EPA's Washington, DC headquarters. Read more>
About ICAPO
The International Council on Animal Protection in OECD Programmes (ICAPO) seeks to ensure the widest possible integration of alternative methods in the Organisation for Economic Co-operation and Development's (OECD) influential guidelines and programmes. The OECD is an economic alliance of 30 of the world's industrialised countries. Based in Paris, the OECD co-ordinates the development of standardised chemical testing guidelines which are then adopted by the member countries. The OECD also co-ordinates the development of chemical testing programmes, such as its current programme on endocrine disruptors.
Recent News and Updates
OECD makes AOP Knowledge Base and AOP Wiki publicly available
September 25 the OECD released the Adverse Outcome Pathway Wiki, part of a larger set of tools termed the AOP Knowledge Base. The Wiki is the first in a set of tools that will allow the building of Adverse Outcome Pathways via scientific crowd-sourcing. It is envisioned that collecting available data on chemical-response and response-response interactions and organizing these data into an AOP framework will speed progress in predicting the toxicity of chemicals without whole animals.
Learn more about the AOP Wiki here and the OECD AOP Program here. The scientific literature is now replete with examples of particular AOPs and uses for them. This paper provides a list of key resources you may wish to consult
NOECD QSAR Toolbox Version 3.1 Available
The OECD maintains the QSAR Toolbox, which is a set of computational tools that can help users group chemicals into categories to fill information gaps without new testing. QSARToobox.org contains instructions on how to download the software, which is freely available, and tutorials and guidance documents for filling specific endpoints. ICAPO has contributed financial and policy support to the development of the toolbox.
Test No. 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)
Test No. 431: In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method
Test No. 439: In Vitro Skin Irritation - Reconstructed Human Epidermis Test Method
Test No. 443: Extended One-Generation Reproductive Toxicity Study(Significant reduction in animal numbers)
TG 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants
Animal Protection Through Participation in the Organisation for Economic Cooperation and Development: The ICAPO Model: A poster presented at the 8th World Congress for Alternatives and Animal Use in the Life Sciences in Montreal in 2011
Test guidelines adopted in 2010 and 2011:
TG 456: H295R Steroidogenesis Assay
TG 439: In Vitro Skin Irritation