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"ICAPO seeks to ensure the widest possible integration of alternative methods in the OECD's influential guidelines and programmes."
NEW: OECD makes AOP Knowledge Base and AOP Wiki publicly available
September 25 the OECD released the Adverse Outcome Pathway Wiki, part of a larger set of tools termed the AOP Knowledge Base. The Wiki is the first in a set of tools that will allow the building of Adverse Outcome Pathways via scientific crowd-sourcing. It is envisioned that collecting available data on chemical-response and response-response interactions and organizing these data into an AOP framework will speed progress in predicting the toxicity of chemicals without whole animals.
Learn more about the AOP Wiki here and the OECD AOP Program here. The scientific literature is now replete with examples of particular AOPs and uses for them. This paper provides a list of key resources you may wish to consult.
The International Council on Animal Protection in OECD Programmes (ICAPO) seeks to ensure the widest possible integration of alternative methods in the Organisation for Economic Co-operation and Development’s (OECD) influential guidelines and programmes. The OECD is an economic alliance of 30 of the world's industrialised countries. Based in Paris, the OECD co-ordinates the development of standardised chemical testing guidelines which are then adopted by the member countries. The OECD also co-ordinates the development of chemical testing programmes, such as its current programme on endocrine disruptors.
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The OECD maintains the QSAR Toolbox, which is a set of computational tools that can help users group chemicals into categories to fill information gaps without new testing. QSARToobox.org contains instructions on how to download the software, which is freely available, and tutorials and guidance documents for filling specific endpoints. ICAPO has contributed financial and policy support to the development of the toolbox.
Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage
Test No. 443: Extended One-Generation Reproductive Toxicity Study(Significant reduction in animal numbers)
Animal Protection Through Participation in the Organisation for Economic Cooperation and Development: The ICAPO Model: A poster presented at the 8th World Congress for Alternatives and Animal Use in the Life Sciences in Montreal in 2011
Test guidelines adopted in 2010 and 2011:
©2008 International Council on Animal Protection in OECD Programmes (ICAPO)